Multi-state Modeling of Biomolecules

Multi-state Modeling of Biomolecules

Multi-state modeling of biomolecules refers to a series of techniques used to represent and compute the behavior of biological molecules or complexes that can adopt a large number of possible functional states. Biological signaling systems often rely on complexes of biological macromolecules that can undergo several functionally significant modifications that are mutually compatible. Thus, they...

Modeling adaptation in multi-state resource systems

Fast Surface Based Electrostatics for biomolecules modeling

We analyze de ciencies of commonly used Coulomb approximations in Generalized Born solvation energy calculation models and report a development of a new fast surface-based method (FSBE) for numerical calculations of the solvation energy of biomolecules with charged groups. The procedure is only a few percents wrong for molecular con gurations of arbitrary sizes, provides explicit values for the...

Reliability Modeling of Circuits with Multi-State Aging Gates

As electronic devices are being scaled towards single digit nanometers, the frequency of errors that such nanocircuits will exhibit is expected to increase sharply. This is both a warning sign and a call to arms for including reliability/yield from the very early circuit design phases as a fourth optimization parameter (besides area, power and speed). In this paper we present an approach for re...

Multi-State Reliability Modeling of A Manufacturing Cell

A Manufacturing cell consists of a machine served by a loading and unloading robot and a pallet handling system, which moves a batch of parts into and out of the system. In this study, a stochastic model is developed to analyze performance measures of a cell, which is allowed to operate under multi-states including degraded mode. The model is used to determine state probabilities of the system,...